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TAM is О± hydroxylated by cytochrome P450 3A4 followed by O sulfonation by hydroxysteroid sulfotransferase, and reacts with guanine residues in DNA, resulting in the formation of О± N 2 deoxyguanosinyl tamoxifen adducts doxycycline for bronchitis Maioli S, Leander K, Nilsson P, Nalvarte I

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