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Although the presence of HER2 amplification does not preclude a meaningful response to an AI in the neoadjuvant setting Ellis et al, 2001; Smith et al, 2005, HER2 positivity is associated with a lower suppression of Ki67, a marker of cell proliferation, in response to either tamoxifen or letrozole Ellis et al, 2006, suggesting treatment resistance to endocrine therapy alone lasix for swelling

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